C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 19/56 (2006.01) C12N 1/20 (2006.01) C12P 15/00 (2006.01) C12P 19/60 (2006.01) C12P 29/00 (2006.01)
Patent
CA 2113871
Disclosed herein are a novel strain of Streptomyces and a method for the production of aclacinomycins A, B, Y and aglycone thereof by cultivating the same. Streptomyces lavendofoliae DKRS (KCTC 0092BP) of the present invention is capable of producing aclacinomycins A, B, Y and aglycone with higher yield. Further, it is possible to selectively produce aclacinomycin A or Y by adjusting pH of the cultured broth of Streptomyces lavendofoliae DKRS to 4.4 or 4.6 with acetate buffer or hydrochloric acid, respectively.
Bartochevichi Y. E.
Cho Won T.
Domracheva A. G.
Kim Hak R.
Kim Myung K.
Dongkook Pharmaceutical Co. Ltd.
Kwon Ki Beom
R. William Wray & Associates
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