A structure-based approach to design inhibitors of...

C - Chemistry – Metallurgy – 07 – C

Patent

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C07C 237/24 (2006.01) A61K 31/16 (2006.01) A61K 31/4164 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) C07D 233/54 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2373182

A method for the structure-based identification and selection of inhibitors of processivity factor binding to protein is disclosed herein. Characterization of the protein/processivity factor interface is given. Methods for the structure-based inhibition of processivity factor binding to protein are also given. One embodiment includes a class of peptidomimetics that mimic helical portions of proteins. In addition, methods of treatment of various diseases are given, using the inhibitors of the invention.

On décrit un procédé qui permet d'identifier et de sélectionner sur base de la structure, des inhibiteurs du facteur de processivité se liant à une protéine. La caractérisation de l'interface facteur de processivité/protéine est donnée ainsi que des procédés assurant l'inhibition sur la base de la structure du facteur de processivité se liant à une protéine. Une forme de réalisation comprend une classe de peptidomimétiques qui imitent les parties hélicoïdales de protéines. En outre, des procédés de traitement de diverses maladies sont présentés dans lesquels on utilise les inhibiteurs selon la présente invention.

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