A structured peptide scaffold for displaying turn libraries...

Details A structured peptide scaffold for displaying turn libraries... A structured peptide scaffold for displaying turn libraries...

C - Chemistry, Metallurgy

07

K

C07K 7/64 (2006.01) C12N 15/10 (2006.01)

Patent

CA 2502243

The invention is directed to a model system for structure-activity analysis of peptide or protein molecules involved in important biological processes. Provided by the invention are combinatorial peptide libraries comprising disulfide-constrained cyclic peptides with sequences favorable for energy stabilized conformations. One aspect of the invention is directed to cyclic peptide scaffolds that present .beta.-hairpin structure in solution. Methods of selecting and using such peptide scaffolds are provided herein, which are useful for mimicking in vivo molecular interactions and designing therapeutic agents. Thus, the invention has profound utility for biological studies and drug development.

L'invention concerne un système de modèles destiné à l'analyse de l'activité structurelle de molécules peptidiques ou protéiques impliquées dans des processus biologiques importants. L'invention concerne notamment des bibliothèques de peptides de combinaison contenant des peptides cycliques à contrainte bisulfure, présentant des séquences favorables à des conformations à stabilisation énergétique. Dans un mode de réalisation, l'invention concerne des échafaudages de peptides cycliques présentant une structure en épingle à cheveux de type B en solution. L'invention concerne également des procédés de sélection et d'utilisation de tels échafaudages peptidiques servant à simuler des interactions moléculaires in vivo et à déterminer des agents thérapeutiques. Par conséquent, la présente invention se révèle très utile pour des études biologiques et le développement de médicaments.

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