C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 19/00 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61K 51/10 (2006.01) A61M 1/38 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) G01N 33/554 (2006.01) G01N 33/564 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2144738
The present invention is based on the novel observation that upon stimulation of resting myeloid cells, not all of the Mac-1 molecules expressed by the cell become activate. Only select subpopulations of Mac-1 molecules are activated and become cap- able of binding ligand. Further, the activated Mac-1 molecules were found to possess activation specific epitopes which distin- guishes them from non-activated Mac-1 molecules. Based on these observations antibodies are described which selectively bind activated Mac-1 molecules but are substantially incapable of binding non-activated Mac-1.
Diamond Michael
Springer Timothy A.
Center For Blood Research Inc.
Gowling Lafleur Henderson Llp
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