A substance or composition for the treatment of cancer

Details A substance or composition for the treatment of cancer A substance or composition for the treatment of cancer

C - Chemistry, Metallurgy

07

F

C07F 19/00 (2006.01) A61K 31/295 (2006.01) A61P 35/04 (2006.01) C07F 17/02 (2006.01)

Patent

CA 2430685

A substance for use in the treatment of cancer, includes a compound selected from metallocenyl .beta.-diketones Mc-CO-CZ1Z2-CO-R. Mc is Fc (ferrocenyl), Rc (ruthenocenyl) or Oc (osmocenyl), R is H, alkyl or aryl and Z1 and Z2 are H, alkyl, aryl or substituted alkyl, ferrocenyl, the enol forms of the .beta.- diketones and metal complexes of the .beta.-diketones of the general formula M(.beta.-diketonato)A1, M(.beta.-diketonato)A1A2, M(.beta.-diketonato)A1B1B2, M(.beta.-diketonato)B1B2 and M(.beta.-diketonato)B1B2B3B4. M is Rh or Ir, A1 and A2 are cyclic dienes having 6 - 8 carbons, or linear alkenes having 2-7 carbons. B1, B2, B3 and B4 are selected from CO, P(R1R2 R3), P(OR1)(OR2)(OR3), R4 and X in which R1,R2, R3 and R4 are independently alkyl, phenyl or ferrocenyl, and X is a halide or a pseudohalide.

La présente invention concerne une substance destinée au traitement anticancéreux, qui comprend un composé choisi parmi les métallocényl .beta.-dicétones Mc-CO-CZ¿1?Z¿2?-CO-R. Mc est Fc (ferrocényle), Rc (ruthénocényle) ou Oc (osmocényle), R est H, alkyle ou aryle et Z¿1? et Z¿2? sont H, alkyle, aryle ou alkyle ou ferrocényle substitués, les formes enol des .beta.-dicétones, les complexes métalliques des .beta.-dicétones de la formule générale M(.beta.-dicétonato)A?1¿, M(.beta.-dicétonato)A?1¿A?2¿, M(.beta.-dicétonato)A?1¿A?2¿B?1¿B?2¿, M(.beta.-dicétonato)B?1¿B?2¿ et M(.beta.-dicétonato)B?1¿B?2¿B?3¿B?4¿. M est Rh ou Ir, A?1¿ et A?2¿ sont des diènes cycliques renfermant de 6 à 8 atomes de carbone ou des alcènes linéaires renfermant de 2 à 7 carbones. B?1¿, B?2¿, B?3¿ et B?4¿ sont choisis entre CO, P(R?1¿R?2¿R?3¿), P(OR?1¿)(OR?2¿)(OR?3¿), R?4¿ et X où R?1¿,R?2¿, R?3¿ et R?4¿ sont indépendamment alkyle, phényle ou ferrocényle, et X est un halogénure ou un pseudohalogénure.

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