C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/50 (2006.01)
Patent
CA 2335328
7- (1, 1-Dimethylethyl)-6-(2-ethyl- 2H- 1, 2, 4- triazol- 3-ylmethoxy) -3- (2- fluorophenyl) - 1,2,4-triazolo[4,3-b]pyridazine, and pharmaceutically acceptable salts thereof, are selective ligands for GABA A receptors, in particular having high affinity for the .alpha.2 and/or .alpha.3 subunit thereof, and are accordingly of benefit in the treatment and/or prevention of disorders of the central nervous system, including anxiety and convulsions.
L'invention concerne une 7- (1, 1- Diméthyléthyl) -6-(2 -éthyl- 2H- 1, 2, 4- triazol- 3-ylméthoxy) -3- (2-fluorophényl) -1,2,4-triazolo[4,3- b]pyridazine et ses sels acceptables du point de vue pharmaceutique, qui représentent des ligands sélectifs de récepteurs de GABAA, et possèdent notamment une grande affinité pour leurs sous-unités alpha 2 et/ou alpha 3 et sont par conséquent d'une grande utilité dans le traitement et/ou la prévention de troubles du système nerveux central, y compris l'anxiété et les convulsions.
Carling William Robert
Castro Pineiro Jose Luis
Cowden Cameron John
Davies Antony John
Madin Andrew
Merck Sharp & Dohme Limited
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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