C - Chemistry – Metallurgy – 08 – L
Patent
C - Chemistry, Metallurgy
08
L
C08L 89/00 (2006.01) A61L 15/32 (2006.01) A61L 15/42 (2006.01) A61L 24/10 (2006.01) C08J 3/02 (2006.01) C08J 7/04 (2006.01)
Patent
CA 2435425
A suspension of fibrinogen, thrombin, alcohol and optionally aprotinin is obtained by mixing fibrinogen in alcohol with thrombin in alcohol. The suspension contains fibrinogen and thrombin particles with a Folk Ward mean diameter of 25 - 100 m. The thrombin may be human, bovine or recombinant. The fibrinogen may be human or recombinant. A method for coating a carrier, such as a collagen sponge, with the suspension, and a method for drying the coating is disclosed. The coated collagen carrier may be used as a ready-to-use absorbable composition for tissue gluing, tissue sealing and haemostasis wherein the carrier is coated with solidly fixed components of fibrin glue, i.e. fibrinogen and thrombin.
La présente invention concerne une suspension à base de fibrinogène, de thrombine, d'alcool, et éventuellement d'aprotinine, obtenue par mélange de fibrinogène dans l'alcool avec de la thrombine dans l'alcool. La suspension contient des particules de fibrinogène et de thrombine d'un diamètre moyen de Folk Ward de 25 à 100 ?m. La thrombine peut être d'origine humaine ou bovine, ou résulter d'une recombinaison. L'invention concerne également un procédé d'enrobage d'un support tel qu'une éponge de collagène, avec la suspension, et un procédé de séchage de l'enrobage. Le support de collagène enrobé convient particulièrement comme composition absorbable prête à l'emploi pour le collage des tissus, la fermeture de tissus et l'hémostase, auquel cas, le support est enrobé de composants solidement maintenus de colle fibrinique, c'est-à-dire fibrinogène et thrombine.
Nycomed Pharma As
Sim & Mcburney
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