C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A61K 31/713 (2006.01) A61K 48/00 (2006.01) A61K 49/00 (2006.01) A61P 35/00 (2006.01) C07K 14/47 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2470903
The present invention provides a polynucleotide comprising a RNA polymerase III promoter, a region encoding a siRNA, and a transcriptional termination element comprising five consecutive thymine residues. The invention also provides for vectors, cells and non-human transgenic animal comprising the polynucleotides of the invention as well as their use in medicaments for various conditions.
La présente invention concerne un polynucléotide contenant un promoteur d'ARN polymérase III, une région codant un ARNsi, et un élément terminal de transcription comportant cinq résidus thymine consécutifs. L'invention concerne également des vecteurs, des cellules et un animal transgénique non humain contenant les polynucléotides selon l'invention, ainsi que l'utilisation desdits polynucléotides dans des médicaments destinés à différents troubles.
Agami Reuven
Brummelkamp Thijn
Cancer Research Technology Limited
Smart & Biggar
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