C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/04 (2006.01) A61K 31/4439 (2006.01) A61P 1/04 (2006.01) A61P 11/00 (2006.01) A61P 11/06 (2006.01) A61P 29/00 (2006.01) C07D 413/04 (2006.01) C07D 417/04 (2006.01)
Patent
CA 2649813
The invention provides compounds of formula (1) wherein R1, R3, R4, R5, R6, R14, X and W are as defined in the specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are inhibitors of human neutrophil elastase.
L'invention concerne des composés de formule (1) dans laquelle R<SUP>1</SUP>, R<SUP>3</SUP>, R<SUP>4</SUP>, R<SUP>5</SUP>, R<SUP>6</SUP>, R<SUP>14</SUP>, X et W sont définis dans la spécification, ainsi que leurs isomères optiques, racémates et tautomères et leurs sels pharmaceutiquement acceptables. Elle concerne également des processus de leur préparation, des compositions pharmaceutiques les contenant et leur utilisation en thérapie. Les composés sont des inhibiteurs de l'élastase neutrophile humaine.
Hansen Peter
Lawitz Karolina
Lepisto Matti
Lonn Hans
Ray Asim
Astrazeneca Ab
Fetherstonhaugh & Co.
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