A system, method, and luminescent marker for improved...

A - Human Necessities – 61 – B

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A61B 5/00 (2006.01) G01N 21/47 (2006.01) G01N 21/64 (2006.01)

Patent

CA 2760783

A method and system for luminescence molecular imaging or tomography of a region of interest in a scattering medium is disclosed. The system comprises a non-linear luminescent marker material arranged in the scattering medium. Contrast and resolution of the imaging or tomography is thus improved. The non-linear marker is for instance configured to upconvert incoming light of an illumination wavelength. The non-linear power dependence of the marker enables further improvement of the imaging by using images taken with two or more excitation beams simultaneously.

La présente invention concerne un procédé et un système pour l'imagerie de luminescence moléculaire ou la tomographie d'une région d'intérêt dans un milieu de diffusion. Le système comprend un matériau marqueur luminescent non linéaire agencé dans le milieu de diffusion. Le contraste et la résolution de l'imagerie ou la tomographie est ainsi amélioré. Le marqueur non linéaire est, par exemple, configuré pour la conversion ascendante de lumière d'entrée d'une longueur d'onde d'illumination. La dépendance de la puissance non linéaire du marqueur permet une amélioration supplémentaire de l'imagerie en utilisant des images prises avec deux faisceaux d'excitation ou plus simultanément.

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