A systematic approach to the analysis of gene function

Details A systematic approach to the analysis of gene function A systematic approach to the analysis of gene function

C - Chemistry, Metallurgy

12

Q

C12Q 1/00 (2006.01) C12M 1/34 (2006.01) C12N 5/06 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2403556

In order to identify, validate, and prioritize potential therapeutic targets, it is advantageous to understand the roles these potential therapeutic targets play within the biological systems network. Stimulation of specific sets, or matrices, of cells followed by multiple time point measurements are used to capture temporal changes exhibited by the different biochemical and genetic elements within cells. The response of these elements to various stimuli are compared and correlated, genetic responses are further correlated to phenotypic responses. The methods and cell matrices of the present invention provide a user with ways to decipher these biochemical and genetic functions, and thereby evaluate various cellular components as potential therapeutic targets.

Pour identifier, valider et classer par ordre de priorité des cibles thérapeutiques potentielles, il est avantageux de comprendre les rôles joués par lesdites cibles thérapeutiques au sein du réseau des systèmes biologiques. La stimulation d'ensembles spécifiques, ou de matrices, de cellules, suivie de multiples mesures ponctuelles dans le temps sont utilisées pour la capture de changements temporels présentés par les différents éléments biochimiques et génétiques dans les cellules. La réponse de ces éléments à divers stimuli est comparée et corrélée et les réponses génétiques sont encore corrélées à des réponses phénotypiques. Les procédés et matrices cellulaires de l'invention permettent de fournir à l'utilisateur des moyens de déchiffrage de ces fonctions biochimiques et génétiques, et d'évaluer divers composants cellulaires en tant que cibles thérapeutiques potentielles.

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