A target for therapeutic reagents to stop the production of...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/11 (2006.01) A61K 31/70 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) C07H 21/02 (2006.01)

Patent

CA 2270360

An mRNA translation control element in the coding region of the human APP gene is revealed. This stem loop structure can regulate the translation of APP mRNA and also the production of all forms of A.beta.. The latter property can play an important role in the prevention and control of Alzheimer's disease, down syndrome and other related diseases where deposition of beta amyloid may be involved.

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