A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/4166 (2006.01) A61P 19/02 (2006.01)
Patent
CA 2289880
The invention provides a therapeutic agent for intractable vasculitis containing a hydantoin derivative represented by the formula (I) or a pharmaceutically acceptable salt thereof as an effective ingredient. Image [In the formula, each of R1 and R2, which may be the same or different, represents hydrogen, an alkyl group or a cycloalkyl group; and each of X and Y, which may be the same or different, represents hydrogen, hydroxyl group, an alkyl group or an alkoxy group, or X and Y together represent an oxo group.] The compounds of the present invention significantly suppressed the generation of arthritis and arteritis (cutaneous ulcer and auricular infarcted necrosis) which were naturally developed in model animals (MRL/1pr), and further significantly elongated the survival rate of MRL/1pr mice. Consequently, the compound of the invention having low toxicity and less side effects is very useful as a highly safe therapeutic agent for intractable vasculitis such as malignant rheumatoid arthritis.
Ienaga Kazuharu
Naiki Mitsuru
Numazawa Takumi
Okada Tomoyuki
Sawada Kazuyoshi
Kirby Eades Gale Baker
Nippon Zoki Pharmaceutical Co. Ltd.
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