A tnf homologue, tl5

Details A tnf homologue, tl5 A tnf homologue, tl5

C - Chemistry, Metallurgy

12

N

C12N 15/28 (2006.01) A61K 31/70 (2006.01) A61K 38/19 (2006.01) A61K 48/00 (2006.01) C07K 14/52 (2006.01) C07K 14/525 (2006.01) C07K 14/705 (2006.01) C07K 16/24 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2232743

TL5 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing TL5 polypeptides and polynucleotides in the design of protocols for the treatment of chronic and acute inflammation, arthritis, septicemia, autoimmune diseases(e.g., inflammatory bowel disease, psoriasis), transplant rejection, graft vs. host disease, infection, stroke, ischemia, acute respiratory disease syndrome, restenosis, brain injury, AIDS, Bone diseases, cancer(e.g., lymphoproliferative disorders), atherosclerosis, and Alzheimers disease, among others, and diagnostic assays for such conditions.

Divulgation de polypeptides et de polynucléotides TL5 et de méthodes de production de tels polypeptides par des techniques de recombinaison. Sont également dévoilées des méthodes d'utilisation de ces produits dans la conception de protocoles pour le traitement de l'inflammation chronique et aiguë, de l'arthrite, de la septicémie, des maladies auto-immunes (p. ex., la maladie inflammatoire intestinale, le psoriasis), du rejet des greffes, de la réaction du greffon contre l'hôte, de l'infection, de l'accident cérébro-vasculaire, de l'ischémie, de l'atteinte respiratoire aiguë, de la resténose, des lésions cérébrales, du SIDA, des maladies des os, du cancer (p. ex., les affections lymphoprolifératives), de l'athérosclérose et de la maladie d'Alzheimer, entre autres, de même que d'épreuves diagnostiques associées.

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