A topical nanoparticulate spironolactone formulation

Details A topical nanoparticulate spironolactone formulation A topical nanoparticulate spironolactone formulation

A - Human Necessities

61

K

A61K 9/51 (2006.01) A61K 9/06 (2006.01) A61K 31/585 (2006.01) A61K 47/14 (2006.01)

Patent

CA 2509101

The invention relates to a topical nanoparticulate spironolactone formulation comprising nanoparticles having a mean diameter, measured by photon correlation spectroscopy, in the range of from about 300nm to about 900nm. The nanoparticles are incorporated into a crystalline network system comprising a dispersion of solid crystals of polar lipids, said lipids exposing their hydrophilic side outwards and their hydrophobic side inwards towards the spironolactone nanoparticles.

L'invention concerne une préparation topique de spironolactone nanoparticulaire, les nanoparticules ayant un diamètre moyen, mesuré par spectroscopie de corrélation des photons, d'environ 300 nm à 900 nm. Les nanoparticules sont incorporées dans un système de réseau cristallin comprenant une dispersion de cristaux solides de lipides polaires, lesdits lipides exposant leur côté hydrophile à l'extérieur et leur côté hydrophobe à l'intérieur vers les nanoparticules spironolactone.

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