A tramadol n-oxide material, enantiomers and compositions...

Details A tramadol n-oxide material, enantiomers and compositions... A tramadol n-oxide material, enantiomers and compositions...

C - Chemistry, Metallurgy

07

C

C07C 291/04 (2006.01) A61K 31/135 (2006.01)

Patent

CA 2078028

This invention relates to a tramadol N-oxide material, enantiomers and compositions thereof and their use. The tramadol N- oxide material and compositions thereof are pharmacologically useful in treating pain, diarrhea and tussive conditions. The tramadol N- oxide is also subject to less side-effects as compared to pure opiate based compositions, such as abuse liability, tolerance, constipation and respiratory depression. Furthermore, the tramadol N-oxide material when administered orally exhibits analgesia for a longer duration than an equi-analgesic amount of tramadol.

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