A transdermal composition of an antivomiting agent and a...

A - Human Necessities – 61 – K

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Details

A61K 31/46 (2006.01) A61K 9/70 (2006.01) A61K 31/4178 (2006.01) A61K 31/439 (2006.01) A61K 47/04 (2006.01) A61K 47/10 (2006.01) A61K 47/12 (2006.01) A61K 47/14 (2006.01) A61K 47/32 (2006.01) A61K 47/38 (2006.01) A61P 1/08 (2006.01)

Patent

CA 2360300

A transdermal composition of the present invention comprises (a) a matrix containing (i) 20 to 80 % by weight of an alcohol, (ii) 1 to 50 % by weight of a skin penetration enhancer of one or more selected from the group consisting of a fatty acid and a derivative thereof, a fatty alcohol anda derivative thereof, an amide, a terpene, a surfactant and a mixture thereof and (iii) 15 to 80 % by weight of water; and (b) 1 to 15 % by weight, based on the weight of the matrix of an antivomiting agent selected from the group consisting of tropisetron, ondansetron, granisetron and pharmaceutically acceptable salts thereof, which is capable of delivering the antivomiting agent efficiently over a period of a day or more without skin irritation.

Cette invention se rapporte à une composition transdermique qui comprend: (a) une matrice contenant (i) 20 à 80 % en poids d'un alcool, (ii) 1 à 50 % en poids d'un agent favorisant la pénétration dans l'épiderme, choisi dans le groupe constitué par un acide gras et un dérivé de celui-ci, un alcool gras et un dérivé de celui-ci, un amide, un terpène, un tensioactif et un mélange de ceux-ci, et (iii) 15 à 80 % en poids d'eau; et (b) 1 à 15 % en poids calculé sur la base du poids de la matrice, d'un agent antiémétique choisi dans le groupe constitué par du tropisétron, de l'ondensétron, du granisétron et des sels de ceux-ci acceptables sur le plan pharmaceutique, cette composition étant capable de libérer l'agent antiémétique de façon efficace sur une période d'un jour ou davantage sans irritation de la peau.

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