A transformant capable of producing d-amino acid oxidase

Details A transformant capable of producing d-amino acid oxidase A transformant capable of producing d-amino acid oxidase

C - Chemistry, Metallurgy

12

N

C12N 1/19 (2006.01) C12N 9/06 (2006.01) C12N 15/81 (2006.01) C12P 35/00 (2006.01)

Patent

CA 2100987

A Trigonopsis variabilis transformed with a recombinant DNA containing a D-amino acid oxidase gene capable of expressing in Trigonopsis variabilis is provided. A process for transforming Trigonopsis variabilis and a process for preparing 7-.beta.-(5-carboxy-5-oxopenetaneamide)cephalosporanic acid by using a transformant of Trigonopsis variabilis are also provided. The transformant of Trigonopsis variabilis shows high DAO activity and low activity of an esterase which interferes with the preparation of derivatives of cephalo-sporin C. Accordingly, the Trigonopsis variabilis of the present invention enables one to produce derivatives of cephalosporin C. Moreover, the Trigonopsis variabilis of the present invention can be used for the preparation of derivatives of cephalosporin C merely by treating the cells with toluene so that large scale use is practical.

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