A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/04 (2006.01) A61P 11/00 (2006.01) C07K 14/35 (2006.01) C07K 19/00 (2006.01)
Patent
CA 2759583
The present invention discloses a vaccine or immunogenic composition that can be administred to latently infected individuals to prevent reactivation of latent tuberculosis infection caused by species of the tuberculosis complex microorganisms (Mycobacterium tuberculosis., M.bovis, M.africanum), The invention is base on a number of M. tuberculosis derived proteins and protein fragments which are constitutively expressed in different stages of the infection. The invention is directed to the use of these polypeptides, immunologically active fragments thereof and the genes encoding them for immunological compositions such as vaccines.
La présente invention concerne un vaccin ou une composition immunogène qui peut être administrée à des individus infectés de façon latente afin de prévenir une réactivation d'une infection par une tuberculose latente provoquée par des espèces des microorganismes du complexe tuberculose (Mycobacterium tuberculosis, M.bovis, M.africanum). L'invention se fonde sur un certain nombre de protéines et de fragments de protéine issus de M. tuberculosis qui sont exprimés constitutivement à différents stades de l'infection. L'invention concerne l'utilisation de ces polypeptides, des fragments immunologiquement actifs de ceux-ci et des gènes codant pour ceux-ci pour des compositions immunologiques telles que des vaccins.
Andersen Peter
Dietrich Jes
Hoang Truc Thi Kim Than
Lundberg Carina Vingsbo
Borden Ladner Gervais Llp
Statens Serum Institut
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