A-type procyanidins useful in the treatment of nitric oxide...

A - Human Necessities – 61 – K

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Details

A61K 31/353 (2006.01) A61P 9/12 (2006.01)

Patent

CA 2554071

The invention relates to compositions, such as pharmaceuticals, foods, food additives, or dietary supplements, containing A-type procyanidins, and methods of use thereof, for prophylactic or therapeutic treatment of a human or a veterinary animal to treat or prevent responsive health conditions, treat hypertension, cardiovascular disease, coronary artery disease and/or vascular circulation disorders, prevent or reduce the risk of heart attack, stroke, congestive heart failure and/or kidney failure, or to improve blood flow, for example renal blood flow. The composition may optionally contain an additional NO modulating agent and/or a cardiovascular-protective or therapeutic agent, or may be administered in combination with such an agent.

Cette invention porte sur des compositions, telles que des produits pharmaceutiques, des produits alimentaires, des additifs alimentaires ou des compléments alimentaires contenant des procyanidines de type A, ainsi que sur des procédés d'utilisation de celles-ci en vue du traitement prophylactique ou thérapeutique d'un être humain ou d'un animal afin de traiter ou prévenir des états de santé sensibles à NO, de traiter l'hypertension, une maladie cardiovasculaire, une coronaropathie et/ou des troubles de la circulation sanguine, de prévenir ou de réduire le risque de crise cardiaque, d'accident vasculaire cérébral, d'insuffisance cardiaque congestive et/ou d'insuffisance rénale, ou d'améliorer le débit sanguin tel que le débit sanguin rénal. Cette composition peut éventuellement renfermer un agent de modulation de NO supplémentaire et/ou un agent thérapeutique ou de protection cardiovasculaire ou peut être administrée conjointement à un tel agent.

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