A vaccine-induced hepatitis b viral strain and uses thereof

Details A vaccine-induced hepatitis b viral strain and uses thereof A vaccine-induced hepatitis b viral strain and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/51 (2006.01) A61K 39/29 (2006.01) C07K 14/02 (2006.01) C07K 16/08 (2006.01) C12N 7/00 (2006.01) C12N 7/01 (2006.01) C12Q 1/68 (2006.01) C12Q 1/70 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2332173

This invention provides an isolated strain of Hepatitis B virus designated Human Hepatitis B Virus Surface Antigen-~S~-145 Singapore Strain (Glycine to Arginine) which constituent viral genome is deposited under Accession Nos. P97121504, P97121505 and P97121506 with the European Collection of Cell Culture on 15th December 1997. This invention also provides an isolated nucleic acid encoding a polypeptide which is a mutant major surface antigen of a strain of hepatitis B virus, such polypeptide having an amino acid sequence which differs from the amino acid sequence of a major surface antigen of a wild type hepatitis B virus in that the amino acid at position number 145 of such polypeptide is an arginine rather than a glycine, and the purified peptide. This invention further provides an isolated nucleic acid which encodes a peptide, wherein the peptide is encoded by a nucleic acid molecule comprising nucleotides 527 through 595 of SEQ. ID. No. 1, and the purified peptide. This invention also provides various methods using the disclosed isolated nucleic acids and polypeptides. This invention also provides various uses of the viral strain and its proteins.

L'invention concerne une souche isolée de l'hépatite B appelée souche d'antigène-'S'-145 Oon de surface de l'hépatite B humaine (de la glycine à l'arginine) dont le génome viral constitutif a été breveté sous les n· P97121504, P97121505 et P97121506 avec l'ensemble européen de culture cellulaire le 15 décembre 1997. L'invention concerne aussi un acide nucléique isolé codant pour un polypeptide qui est un antigène de surface mutant principal d'une souche de l'hépatite B, ce polypeptide ayant une séquence d'aminoacides différente de la séquence d'un antigène de surface principal d'un type sauvage du virus de l'hépatite B. La différence vient de ce que l'aminoacide en position n· 145 de ce polypeptide est une glycine au lieu d'une arginine. Cette invention concerne également un acide nucléique isolé codant pour un peptide, le peptide étant codé par une molécule d'acide nucléique renfermant des nucléotides de 527 à 595 de SEQ. ID No. 1 et le peptide purifié. L'invention concerne en outre plusieurs procédés d'utilisation des acides nucléiques isolés et de polypeptides. L'invention concerne finalement différentes applications de la souche virale et de ses protéines.

Affiliated with

Also associated with

Rating

A vaccine-induced hepatitis b viral strain and uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with A vaccine-induced hepatitis b viral strain and uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and A vaccine-induced hepatitis b viral strain and uses thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-2064454