C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/30 (2006.01) A61K 39/395 (2006.01) C12N 5/06 (2006.01)
Patent
CA 2534659
The protein and nucleic acid sequences of mesovt2, specific antibodies thereto, methods for targeting and/or inhibiting the growth of cells bearing mesovt2, and methods of use of mesovt2 for diagnosing malignancy are provided. Methods of use of the mesovt2 antibodies in the treatment of certain cancers, particularly cancers that have increased cell surface expression of the mesovt2 antigen, such as pancreatic adenocarcinoma, lung carcinoma, and ovarian cancer, also are provided. The invention also relates to cells expressing the monoclonal antibodies, derivatives, and fragments.
L'invention concerne la protéine et des séquences d'acide nucléique de mesovt2, leurs anticorps spécifiques, des procédés permettant de cibler et/ou d'inhiber la croissance de cellules portant la mesovt2, et des procédés d'utilisation de mesovt2 pour le diagnostic de malignité. L'invention concerne des procédés d'utilisation des anticorps mesovt2 dans le traitement de certains cancers, notamment de cancers qui ont une expression de surface cellulaire accrue de l'antigène mesovt2, tel que l'adénocarcinome pancréatique, la carcinome pulmonaire et le cancer ovarien. L'invention concerne également des cellules exprimant les anticorps monoclonaux, dérivés et fragments.
Ebel Wolfgang
Grasso Luigi
Nicolaides Nicholas E.
Sass Philip M.
Gowling Lafleur Henderson Llp
Morphotek Inc.
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