C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C12N 15/11 (2006.01) C12N 15/85 (2006.01) C12P 21/08 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2275180
A variant human .alpha.7 nicotinic acetylcholine receptor (nAChR) polypeptide is provided wherein the variant contains an amino acid substitution at the valine-274 position of the wild-type human .alpha.7 nAChR. Nucleic acid molecules encoding the variant human .alpha.7 nAChR, vectors and host cells containing such nucleic acid molecules are also provided. In addition, methods are provided for producing the variant as are methods of using such variants for screening compounds for activity at the nAChR.
La présente invention concerne un polypeptide .alpha.7 humain variant du récepteur nicotinique de l'acétylcholine (nAChR), le variant contenant une substitution d'acide aminé en position valine-274 du nAChR .alpha.7 humain de type sauvage. L'invention se rapporte également à des molécules d'acide nucléique codant le nAChR .alpha.7 humain variant, ainsi que des vecteurs et des cellules hôtes contenant ces molécules d'acide nucléique. L'invention concerne enfin des procédés de production des variants ainsi que des procédés d'utilisation de ces variants dans le criblage de composés présentant une activité à l'emplacement du nAChR.
Briggs Clark A.
Gopalakrishnan Murali
Mckenna David G.
Monteggia Lisa M.
Roch Jean-Marc
Abbott Laboratories
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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