A virus-safe blood coagulation factor xiii preparation

Details A virus-safe blood coagulation factor xiii preparation A virus-safe blood coagulation factor xiii preparation

C - Chemistry, Metallurgy

12

N

C12N 9/10 (2006.01) A61K 38/36 (2006.01) A61K 38/45 (2006.01) A61L 2/00 (2006.01) C12N 7/04 (2006.01) C12Q 1/56 (2006.01) G01N 33/86 (2006.01) A61K 38/00 (2006.01) A61L 25/00 (1995.01)

Patent

CA 2128795

The present invention relates to a virus-safe blood coagulation factor XIII preparation, which is obtained by heating an aqueous solution containing the blood coagulation factor XIII having a Specific activity of at least 2 U/mg of total protein, said solution containing less than 10 % of known stabilizers selected from the group consisting of sugars, polyols, amino acids, peptides and carboxylic acids, as well as less than 0.5 mol ammonium sulfate per liter, said heating being effected for a period of time sufficient to inactivate infectious agents, preferably for a period of time of from 30 min to 100 h.

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