A virus which can express tumor angiostatin factor with high...

C - Chemistry – Metallurgy – 12 – N

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C12N 7/01 (2006.01) A61K 48/00 (2006.01) C12N 9/68 (2006.01) C12N 15/19 (2006.01) C12N 15/33 (2006.01)

Patent

CA 2430625

The invention disclosed a virus, which can express tumor angiostatin factor with high efficiency and proliferate in specific tumor cell and the use of it. Said virus mainly propagates in tumor cells and it can specifically kill the tumor cells straightforwardly. By adding the nucleotide sequences encoding tumor angiostatin factor in the non-proliferating necessary region of the viral genome. With the replication of the virus in the tumor cells, the nuclotide sequences encoding the tumor angiostatin factor multiple. So it can express tumor angiostatin factor with high efficiency in specific tumor cell and restrain the forming of the tumor blood vessel, and control the tumor forming, developing and transferring.

L'invention porte sur un virus d'expression efficace d'un facteur d'inhibition du développement des tumeurs dans les vaisseaux sanguins dans les cellules tumorales spécifiques et ses applications. Le virus de cette invention est en mesure, d'une part, de limiter la prolifération des cellules tumorales et, d'autre part, de détruire directement les cellules tumorales par sélection. L'insertion dudit virus dans lesdites cellules tumorales par le biais de séquences nucléotidiques codant ledit facteur d'inhibition du développement de tumeurs dans les vaisseaux sanguins et la réplication du virus au sein des cellules tumorales ont pour effet de multiplier les séquences nucléotidiques du facteur d'inhibition du développement des tumeurs dans les vaisseaux sanguins. Ainsi, l'invention est en mesure d'exprimer avec efficacité le facteur d'inhibition du développement des tumeurs dans les vaisseaux sanguins, d'inhiber le développement de tumeurs dans les vaisseaux sanguins et de réduire la formation, la prolifération et le transfert de tumeurs.

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