A viscosity enhanced ophthalmic solution, having a detergent...

A - Human Necessities – 61 – L

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A61L 12/08 (2006.01) C11D 1/66 (2006.01) C11D 3/00 (2006.01) C11D 3/22 (2006.01) C11D 3/37 (2006.01) G02C 13/00 (2006.01)

Patent

CA 2365542

An ophthalmic solution with viscosity enhancing and detergent properties for contact lenses, comprising one or more physiologically acceptable viscosity enhancing agents in aqueous solution having a non- Newtonian rheological behaviour, and one or more physiologically acceptable non-ionic surfactants. The non-ionic surfactant may be selected among esters of fatty acids, sorbitan polyoxyethylates (i.e. polysorbates, such as "Tween"), or block copolymers polyoxyethylen- polyoxypropylene (i.e. poloxamers, such as "Pluronic"). The viscosity enhancing agent may be selected among hyaluronic acid or its salts with alkali or alkaline-earth metals, ethers or esters of cellulose, chitosans, gellans, alginates or carboxyvinyl polymers of the kind Carbopol® (or carbomer).

L'invention concerne une solution ophtalmique présentant des propriétés d'amélioration de viscosité et détergentes pour lentilles de contact, contenant un ou plusieurs agents améliorant la viscosité, acceptables sur le plan physiologique, dans une solution aqueuse ayant une comportement rhéologique non-newtonien, ainsi qu'un ou plusieurs tensioactifs non ioniques acceptables sur le plan physiologique. Le tensioactif non ionique peut être utilisé parmi des esters d'acides gras, des polyoxyéthylates de sorbitan (par exemple des polysorbates, tels que "Tween"), ou des copolymères bloc polyoxyéthylène-polyoxypropylène (par exemple des poloxamères tels que "Pluronique"). L'agent améliorant la viscosité peut être choisi parmi l'acide hyaluronique ou ses sels avec des métaux alcalins ou alcalino-terreux, des éthers ou esters de cellulose, des chitosanes, des gellanes, des alginates ou des polymères carboxyvinyliques du type Carbopol3 (ou carbomère).

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