A2a adenosine receptor antagonists

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 495/04 (2006.01) A61K 31/5415 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2670788

The present invention relates to novel compounds that are A2A adenosine receptor antagonists, and to their use in treating mammals for various disease states, such as CNS disorders, including the "movement disorders" (Parkinson's disease, Huntington's Chorea, and catalepsy), and cerebral ischemia, excitotoxicity, cognitive and physiological disorders, depression, ADHD, hepatic fibrosis, cirrhosis of the liver, and drug addiction (alcohol, amphetamine, cannabinoids, cocaine, nicotine, and opioids) and to their use in the enhancement of immune response. The invention also relates to methods for the preparation of such compounds, and to pharmaceutical compositions containing them.

La présente invention concerne des composés nouveaux qui sont des antagonistes du récepteur d'adénosine A2A, et leur utilisation dans le traitement de mammifères pour des états de maladies variés. Lesdits états de maladie comprennent les troubles du système nerveux central, incluant les <= troubles du mouvement >= (maladie de Parkinson, chorée de Huntington et catalépsie), l'ischémie cérébrale, l'excitotoxicité, les troubles cognitifs et physiologiques, la dépression, les troubles déficitaires de l'attention avec hyperactivité, la fibrose hépatique, la cirrhose du foie, et la dépendance aux drogues (alcool, amphétamine, cannabinoïdes, cocaïne, nicotine, et opioïdes). L'invention concerne également leur utilisation dans l'amélioration de la réponse immune. Ladite invention concerne enfin des procédés de préparation desdits composés, ainsi que des compositions pharmaceutiques les contenant.

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