C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 1/04 (2006.01) A61K 35/74 (2006.01) C07G 11/00 (2006.01) C12N 1/20 (2006.01) C12P 1/06 (2006.01)
Patent
CA 2075163
X-8826M Abstract of the Invention Fermentation product A87689 is produced by a strain of Amycolatopsis mediterranei selected from NRRL 18815 and NRRL 18851, or an A87689-producing mutant thereof. A87689, its C1-6-alkyl ether and C1-6-alkanoyl ester derivatives and pharmaceutically acceptable salts thereof are phospholipase A2 inhibitors that are useful as antiinflammatory agents. Fermentation products known as BU-3889V, its components and pharmaceutically acceptable salts thereof, are phospholipase A2 inhibitors that are alæo useful as antiinflammatory agents. A87689 compounds, including its C1-6-alkyl ether and C1-6-alkanoyl derivatives, used alone or in combination with nucleoside reverse transcriptase inhibitors, non-nucleoside reverse transcriptase inhibitors and HIV protease inhibitors, are also useful for managing retroviral infections in mammals and are particularly useful for managing HIV and/or AIDS in humans.
Berry Dennis R.
Colacino Joseph M.
Dantzig Anne H.
Debono Manuel
Hamill Robert L.
Eli Lilly And Company
Gowling Lafleur Henderson Llp
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