Aabb-poly(depsipeptide) biodegradable polymers and methods...

C - Chemistry – Metallurgy – 08 – L

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C08L 77/12 (2006.01) A61K 47/34 (2006.01) A61K 47/42 (2006.01) A61L 15/32 (2006.01) A61L 27/22 (2006.01) C07C 67/14 (2006.01)

Patent

CA 2733686

The invention provides AABB-poly(depsipeptide)s (AABB-PDPs), a class of biodegradable polymers composed of a-amino and a-hydroxy acids with material properties suitable for biomedical applications. These AABB-PDPs belong to the family of amino acid- based poly(ester amide)s (PEAs), which are characterized by the presence of alternating ester and amide functionalities. Containing four ether groups per basic unit, these polymers degrade rapidly by biotic or abiotic hydrolytic action to release dispersed bioactive agents at a controlled delivery rate, are non- toxic, produce digestible breakdown products, and are easy to fabricate by solution polycondensation.

Linvention concerne des AABB-poly(depsipeptide)s (AABB-PDP), une classe de polymères biodégradables composée dacides a-aminés et a-hydroxylés présentant des propriétés matérielles appropriées pour des applications biomédicales. Ces AABB-PDP appartiennent à la famille des poly(ester amide)s (PEA) à base dacides aminés, qui sont caractérisés par la présence de fonctionnalités esters et amides en alternance. Contenant quatre groupes éthers par unité de base, ces polymères se dégradent rapidement par une action hydrolytique biotique ou abiotique libérant des agents bioactifs dispersés à une vitesse de délivrance contrôlée, sont non toxiques, donnent des produits de dégradation digestibles et sont faciles à fabriquer par une polycondensation en solution.

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