Aav split-packaging genes and cell lines comprising such...

Details Aav split-packaging genes and cell lines comprising such... Aav split-packaging genes and cell lines comprising such...

C - Chemistry, Metallurgy

12

N

C12N 5/16 (2006.01) C12N 15/63 (2006.01) C12N 15/864 (2006.01)

Patent

CA 2270285

The present invention provides AAV "split-packaging" genes, and packaging cells comprising such genes, for use in the production of high titers of replication-incompetent recombinant AAV vectors that can be used to deliver transgenes of interest to a variety of mammalian cells.

Cette invention a trait à des gènes d'encapsidation fractionnés de virus adéno-associé ainsi qu'à des cellules d'encapsidation comprenant ces gènes, utilisés pour la production de titrages élevés de vecteurs d'AAV de recombinaison, inaptes à la réplication, susceptibles d'être utilisés pour l'apport de transgènes d'intérêt à diverses cellules mammaliennes.

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