Aav vectors for in vivo gene therapy of rheumatoid arthritis

Details Aav vectors for in vivo gene therapy of rheumatoid arthritis Aav vectors for in vivo gene therapy of rheumatoid arthritis

C - Chemistry, Metallurgy

12

N

C12N 15/861 (2006.01) A61K 48/00 (2006.01) A61P 19/02 (2006.01)

Patent

CA 2536471

The present invention relates to the field of adeno-associated virus (AAV) based gene therapy, in particular in vivo gene therapy, of rheumatoid arthritis (RA). The invention provides recombinant AAV virions being highly efficient in delivering genes encoding therapeutic proteins to the arthritic joints, and methods for using such virions in in vivo gene therapy.

L'invention se rapporte au domaine de la thérapie génique par l'intermédiaire d'un virus adéno-associé (AAV), en particulier au traitement par thérapie génique in vivo de la polyarthrite rhumatoïde (PR). L'invention concerne des virions AAV recombinés très efficaces pour le transport de gènes codant pour des protéines thérapeutiques dans les articulations arthritiques, et des méthodes d'utilisation de ces virions pour une thérapie génique in vivo.

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