A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01) A61K 31/7032 (2006.01) A61K 31/7088 (2006.01) A61K 31/80 (2006.01) A61K 39/00 (2006.01) A61K 39/35 (2006.01) A61K 39/39 (2006.01) A61P 11/06 (2006.01) A61P 29/00 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) A61P 37/08 (2006.01)
Patent
CA 2567789
Compositions and methods are provided for enhancing delivery of therapeutic agents. More specifically, compositions and methods are provided for improving antigen delivery to antigen-presenting cells. Conjugates between abasic oligonucleotides and antigen are provided, along with methods for their use in vaccination and in the treatment of cancer, infection, and allergy and asthma. Also provided are conjugates between abasic oligonucleotides and various immunostimulatory nucleic acids, including CpG oligonucleotides, as well as methods of use thereof. Also provided are conjugates between abasic oligonucleotides and various other agonists and antagonists of immunostimulation, as well as methods of use thereof.
L'invention concerne des compositions et des procédés destinés à améliorer l'administration d'agents thérapeutiques. Plus particulièrement, ces compositions et ces procédés permettent d'améliorer l'administration d'antigène dans des cellules présentant de l'antigène. Des conjugués sont réalisés entre des oligonucléotides abasiques et un antigène, avec des procédés destinés à leur utilisation dans la vaccination et dans le traitement du cancer, d'infections, d'allergies et de l'asthme. L'invention concerne également des conjugués réalisés entre des oligonucléotides abasiques et divers acides nucléiques immunostimulatoires, notamment des oligonucléotides CpG, et des procédés d'utilisation de ceux-ci. L'invention concerne enfin des conjugués réalisés entre des oligonucléotides abasiques et divers autres agonistes et antagonistes d'immunostimulation, ainsi que des procédés d'utilisation de ceux-ci.
Forsbach Alexandra
Lipford Grayson B.
Uhlmann Eugen
Wagner Hermann
Coley Pharmaceutical Gmbh
Smart & Biggar
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