Abca-1 elevating compounds against coronary artery disease...

Details Abca-1 elevating compounds against coronary artery disease... Abca-1 elevating compounds against coronary artery disease...

C - Chemistry, Metallurgy

07

D

C07D 319/08 (2006.01) A61K 31/357 (2006.01) A61P 3/06 (2006.01) A61P 9/10 (2006.01)

Patent

CA 2436662

The present invention provides compounds that elevate cellular expression of the ABCA-1 gene, promoting cholesterol efflux from cells and increasing HDL levels in the plasma of a mammal, in particular humans. The compounds are useful for treating coronary artery disease.

L'invention concerne des composés élevant l'expression cellulaire du gène de ABCA-1, ce qui favorise l'écoulement du cholestérol hors des cellules et augmente les niveaux de HDL dans le plasma d'un mammifère, en particulier, un mammifère humain. Ces composés sont utiles pour traiter les coronaropathies.

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