Abca-1 elevating compounds and the use thereof

Details Abca-1 elevating compounds and the use thereof Abca-1 elevating compounds and the use thereof

A - Human Necessities

61

K

A61K 31/7076 (2006.01) A61P 3/00 (2006.01)

Patent

CA 2714516

Disclosed are novel compounds of Formula (1) useful for treating various disease states, in particular, insulin resistance, diabetes, dyslipidemia, coronary artery disease, and inflammation. The compounds of the present invention elevate cellular expression of the ABCA-1 gene as well as increasing the level of ABCA-1 protein, which may result in an increase in HDL levels in the plasma of a mammal, in particular humans.

Linvention concerne de nouveaux composés de formule (1) utiles pour traiter divers états pathologiques, par exemple la résistance à linsuline, le diabète, la dyslipidémie, la maladie coronarienne et une inflammation. Les composés de la présente invention élèvent lexpression cellulaire du gène ABCA-1 et augmentent le taux de protéine ABCA-1, ce qui peut conduire à une augmentation des taux de HDL dans le plasma dun mammifère, par exemple des êtres humains.

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