Abca1 stabilizer

Details Abca1 stabilizer Abca1 stabilizer

A - Human Necessities

61

K

A61K 31/05 (2006.01) A61K 31/122 (2006.01) A61K 31/385 (2006.01) A61P 3/04 (2006.01) A61P 3/06 (2006.01) A61P 9/10 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2553710

It is intended to provide an ABCA1 stabilizer focusing on the HDL neogenesis system which is pharmacologically useful as a preventive/remedy for low HDL cholesterolemia. Namely, an ABCA1 stabilizer, which comprises a bisphenol compound selected from among probucol spiroquinone, probucol diphenoquinone and probucol bisphenol as the active ingredient, enables the continuous and stable express of ABCA1 by a mechanism completely different from those in the conventional art, thereby increasing blood HDL level. Therefore, it is useful as a preventive/remedy for low HDL cholesterolemia, arteriosclerosis, etc.

L'invention porte sur un stabilisateur de l'ABCA1 focalisé sur le système de néogenèse du HDL, et s'avérant pharmacologiquement utile comme remède préventif/curatif de la faible cholestérolémie du HDL. Ledit stabilisateur qui comporte comme principe actif un composé de bisphénol choisi parmi la probucol spiroquinone, la probucol diphéniquinone et le probucol bisphénol, favorise l'expression stable et continue de l'ABCA1 par un mécanisme entièrement différent des mécanismes usuels, ce qui a pour effet un accroissement du HDL sanguin, et constitue un préventif/curatif de la faible cholestérolémie du HDL, de l'artériosclérose, etc.

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