C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/0775 (2010.01) A61K 35/12 (2006.01) A61P 9/00 (2006.01) A61P 25/00 (2006.01) A61P 37/02 (2006.01) C12N 5/10 (2006.01) C07K 14/705 (2006.01)
Patent
CA 2685492
The present invention is directed to purified preparations of dermal mesenchymal stem cells that are characterized by the cell surface expression of the ABCB5 P- glycoprotein. The cells may be used for any purpose that mesenchymal stem cells from other course are used. For instance they may be administered to treat an organ transplant recipient to improve allograft survival or as a treatment to patients with autoimmune diseases such as multiple sclerosis and rheumatoid arthritis.
La présente invention concerne des préparations purifiées de cellules souches mésenchymateuses dermiques qui sont caractérisées par l'expression de la glycoprotéine ABCB5 P à la surface des cellules. Les cellules peuvent être utilisées pour n'importe quelles applications utilisant des cellules souches mésenchymateuses d'autres classes. Par exemple, elles peuvent être administrées pour traiter un receveur de greffon organique en vue d'améliorer la survie de l'allogreffe ou pour traiter des patients souffrant de maladies auto-immunes telles qu'une sclérose en plaques et une polyarthrite rhumatoïde.
Children's Medical Center Corporation
Smart & Biggar
The Brigham And Women's Hospital Inc.
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