Aberrant mitochondrial dna, associated fusion transcripts...

Details Aberrant mitochondrial dna, associated fusion transcripts... Aberrant mitochondrial dna, associated fusion transcripts...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07H 21/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C07K 19/00 (2006.01) C12N 15/62 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/574 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2756824

The present invention provides novel mitochondrial fusion transcripts, the parent mutated mtDNA molecules, and the resulting translation products (proteins) for predicting, diagnosing and/or monitoring cancer. Hybridization probes complementary thereto for use in the methods of the invention are also provided.

L'invention concerne de nouveaux transcrits de fusion mitochondriale, les molécules d'ADN mitochondrial (ADNmt) mutées parentes, ainsi que les produits de traduction résultants (protéines), utiles dans la prédiction, le diagnostic et/ou la surveillance du cancer. L'invention concerne également des sondes d'hybridation complémentaires, destinées à être utilisées dans les méthodes de l'invention.

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