C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/244, 402/318
C07D 319/12 (2006.01) A61K 31/765 (2006.01) A61L 24/04 (2006.01) C08G 63/08 (2006.01) C08G 63/82 (2006.01) C11C 3/00 (2006.01)
Patent
CA 1260488
ABSTRACT The triglyceride castor oil is reacted with the lactones glycolide and/or lactide in such a manner as to pro- duce resins with properties which range from oils to waxes at room temperature. The waxes may be used directly as syn- thetic absorbable haemostatic agents for the control of osseous haemorrhage. A biocompatible powder such as calcium stearate may also be mixed with the copolyester resins to produce a wax useful in the stated role. Water soluble bio- compatible components such as dextran may also be added. The preferred haemostatic agent is a 50/50 w/w mixture of calcium stearate powder and resin with a glycolide:castor oil molar ratio of 6:1 with approximately 80% of the glycolide present as a polymeric solid which melts above room temperature.
513258
Ethicon Ltd.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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