Absorption enhancers for topical pharmaceutical formulations

Details Absorption enhancers for topical pharmaceutical formulations Absorption enhancers for topical pharmaceutical formulations

A - Human Necessities

61

K

A61K 47/18 (2006.01) A61K 9/00 (2006.01)

Patent

CA 2178594

Biodegradable absorption enhancers, especially useful in pharmaceutical formulations are compounds comprising a novel group of esters of long chain aliphatic acids with N,N-disubstituted amino alcohols. For example, the penetration promoting ability of 1-(N,N-dimethylamino)-2-propanol myristate is compared to typical enhancers and controls.

L'invention concerne des composés biodégradables particulièrement utiles pour améliorer l'abosrption de formulations pharmaceutiques. Il s'agit d'un nouveau groupe d'esters d'acides aliphatiques à chaîne longue et d'aminoalcools N,N-substitués. Par exemple, on compare la pénétration produite par l'adjuvant myristate de 1-(N,N-diméthylamino)-2-propanol à celle produite par un adjuvant traditionnel et à la pénétration observée sans adjuvant.

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