Absorption enhancers such as bht, bha or propylgallate

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/19 (2006.01) A61K 9/48 (2006.01) A61K 38/00 (2006.01) A61K 47/10 (2006.01) A61K 47/14 (2006.01)

Patent

CA 2522098

The invention provides a pharmaceutical composition comprising a mixture of (a) an active macromolecular principle, and (b) an aromatic alcohol absorption enhancer chosen from butylated hydroxy toluene, butylated hydroxy anisole and analogues and derivatives thereof, wherein the aromatic alcohol absorption enhancer is present in an amount by weight greater than or equal to that of the active macromolecular principle, and further comprises a pharmaceutical composition comprising a mixture of (a) an active macromolecular principle, (b) an aromatic alcohol absorption enhancer chosen from propyl gallate, butylated hydroxy toluene, butylated hydroxy anisole and analogues and derivatives thereof, wherein the aromatic alcohol absorption enhancer is present in an amount by weight greater than or equal to that of the active macromolecular principle, and (c) a solubilisation aid capable of increasing the solubility of the aromatic alcohol absorption enhancer in aqueous media.

L'invention concerne une composition pharmaceutique comprenant un mélange de : (a) un principe actif macromoléculaire, et (b) un activateur d'absorption d'alcool aromatique choisi dans le groupe constitué par l'hydroxytoluène butylé, l'hydroxyanisole butylé et des analogues et dérivés de ceux-ci, la quantité en poids de l'activateur d'absorption d'alcool aromatique étant supérieure ou égale à celle du principe actif macromoléculaire. L'invention concerne de plus une composition pharmaceutique comprenant un mélange de : (a) un principe actif macromoléculaire, (b) un activateur d'absorption d'alcool aromatique choisi dans le groupe constitué par le gallate de propyle, l'hydroxytoluène butylé, l'hydroxyanisole butylé et des analogues et dérivés de ceux-ci, la quantité en poids de l'activateur d'absorption d'alcool aromatique étant supérieure ou égale à celle du principe actif macromoléculaire, et (c) un agent de solubilisation permettant d'accroître la solubilité de l'activateur d'absorption d'alcool aromatique en milieu aqueux.

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