Abuse resistant drugs, method of use and method of making

Details Abuse resistant drugs, method of use and method of making Abuse resistant drugs, method of use and method of making

A - Human Necessities

61

K

A61K 9/24 (2006.01)

Patent

CA 2696341

An abuse resistant oral pharmaceutical composition, comprising: a barrier layer, comprising a first polymer; a diffusion layer, comprising a second polymer, substantially covering the barrier layer, wherein the diffusion layer is bonded to the barrier layer and comprises a drug that is substantially homogeneously distributed within the second polymer and diffuses from the diffusion layer within the gastrointestinal (GI) tract; and optionally an expansion layer comprising an expandable polymer, wherein the expansion layer is substantially covered by the barrier layer. Methods of making the same and methods of using the same are also provided.

La présente invention concerne une composition pharmaceutique à usage oral résistant aux abus, comprenant : une couche de barrière, comprenant un premier polymère ; une couche de diffusion, comprenant un second polymère, recouvrant sensiblement la couche de barrière, la couche de diffusion étant liée à la couche de barrière et comprenant un médicament qui est sensiblement distribué de manière homogène dans le second polymère et se diffuse à partir de la couche de diffusion dans l'appareil gastro-intestinal (GI) ; et éventuellement, une couche d'expansion comprenant un polymère expansible, la couche d'expansion étant sensiblement recouverte par la couche de barrière. Des procédés de fabrication et d'utilisation sont également décrits.

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