Abuse resistant formulation

Details Abuse resistant formulation Abuse resistant formulation

A - Human Necessities

61

K

A61K 9/16 (2006.01) A61K 31/437 (2006.01) A61K 31/4468 (2006.01) A61P 25/04 (2006.01)

Patent

CA 2753664

There is provided a sustained-release pharmaceutical composition comprising a solid, continuous network comprising an excipient with a high mechanical strength, which network also comprises pores, within which pores is interspersed a mixture of an active ingredient and a film-forming agent, characterised in that said pores are formed during the production of the composition. Compositions of the invention find particularly utility as abuse- resistant formulations comprising opioid analgesics that may be employed in the treatment of chronic pain.

La présente invention porte sur une composition pharmaceutique à libération prolongée comprenant un réseau continu solide comprenant un excipient dont la résistance mécanique est élevée, lequel réseau comprend également des pores à l'intérieur desquels est dispersé un mélange d'un principe actif et d'un agent filmogène, caractérisé en ce que lesdits pores sont formés durant la fabrication de la composition. Les compositions de l'invention trouvent une utilité particulière en tant que formulations permettant d'empêcher une consommation abusive, incluant des analgésiques opioïdes, pouvant servir pour le traitement d'une douleur chronique.

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