Abuse-resistant opioid solid dosage form

Details Abuse-resistant opioid solid dosage form Abuse-resistant opioid solid dosage form

A - Human Necessities

61

K

A61K 31/485 (2006.01) A61K 9/20 (2006.01) A61K 31/137 (2006.01) A61K 31/444 (2006.01) A61K 45/06 (2006.01)

Patent

CA 2486075

The present invention pertains to a solid dosage form comprising an analgesically effective amount of opioid analgesic and an opioid abuse- deterring amount of a nontoxic N-methyl-D-aspartate receptor antagonist contained in a carrier which isolates, or separates, the antagonist from the opioid analgesic. The nontoxic N-methyl-D-aspartate receptor antagonist is released and made available only when the dosage form is misused, as would be the case when the dosage form is crushed or dissolved and thereafter administered in a manner other than that indicated, e.g., by injection or intranasally.

L'invention concerne une forme pharmaceutique solide renfermant une quantité analgésique efficace d'analgésique opioïde et une quantité d'antagoniste vis-à-vis du récepteur de N-méthyl-D-aspartate, non toxique, qui permet d'éviter les abus d'opioïdes, contenue dans un vecteur qui isole ou sépare l'antagoniste de l'analgésique opioïde. Cet antagoniste est libéré et rendu utilisable uniquement lorsque la forme pharmaceutique fait l'objet d'une utilisation abusive, à savoir par exemple broyage ou dissolution puis administration s'écartant des instructions fournies, du type injection ou administration intranasale.

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