Abuse-resistant pharmaceutical compositions of opioid agonists

A - Human Necessities – 61 – K

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A61K 9/50 (2006.01)

Patent

CA 2655835

Provided herein is a pharmaceutical composition comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing. such a pharmaceutical composition are also provided.

La présente invention porte sur une composition pharmaceutique comprenant un antagoniste, un agoniste, une couche scellante et un polymère séquestrant, l'antagoniste, l'agoniste, la couche scellante et le ou les polymères séquestrants étant tous des composants d'une unique unité, la couche scellante séparant physiquement l'antagoniste de l'agoniste. La présente invention porte également sur des méthodes de fabrication d'une telle composition pharmaceutique.

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