Abuse resistant transmucosal drug delivery device

Details Abuse resistant transmucosal drug delivery device Abuse resistant transmucosal drug delivery device

A - Human Necessities

61

K

A61K 9/00 (2006.01) A61K 31/4468 (2006.01) A61K 31/485 (2006.01) A61K 45/06 (2006.01)

Patent

CA 2629046

The present invention relates to a solid pharmaceutical dosage form for abusable drug delivery with reduced illicit abuse potential. The dosage form is presented as a bioerodable transmucosal delivery device that includes an abusable drug and an antagonist to the abusable drug associated with an abuse- resistant matrix. The devices of the invention may be in the form of a layered film or a tablet. Upon application in a non-abusive manner, the device adheres to the mucosal surface, providing transmucosal drug delivery of the drug with minimal absorption of the antagonist into systemic circulation.

La présente invention concerne une forme solide de dosage pharmaceutique pour l'administration de médicaments stupéfiants qui réduit le risque d'une utilisation illicite. La forme de dosage est présentée sous la forme d'un dispositif bioérodable d'administration transmucosale qui comprend un médicament stupéfiant et un antagoniste du médicament stupéfiant associé à une matrice qui résiste aux abus. Le dispositif selon l'invention peut présenter la forme d'un film stratifié ou d'un comprimé. Lorsque le médicament est administré licitement, le dispositif adhère à la surface mucosale en administrant le médicament par voie mucosale avec absorption minimale de l'antagoniste dans la circulation systémique.

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