Acat inhibitors

Details Acat inhibitors Acat inhibitors

C - Chemistry, Metallurgy

07

C

167/179, 260/329

C07C 237/28 (2006.01) A61K 31/165 (2006.01) A61K 31/27 (2006.01) A61K 31/33 (2006.01) C07C 233/07 (2006.01) C07C 233/11 (2006.01) C07C 237/04 (2006.01) C07C 237/20 (2006.01) C07C 237/22 (2006.01) C07C 237/24 (2006.01) C07C 271/12 (2006.01) C07C 271/20 (2006.01) C07C 271/22 (2006.01) C07C 271/34 (2006.01) C07C 275/50 (2006.01) C07C 311/19 (2006.01) C07C 323/60 (2006.01) C07C 327/44 (2006.01) C07C 335/12 (2006.01) C07C 335/18 (2006.01) C07C 335/20 (2006.01) C07D 209/20 (2006.01) C07D 213/56 (2006.01) C07D 295

Patent

CA 2024300

ABSTRACT The present invention are novel amino acid amide compounds of the following general formula which inhibit the enzyme acylcoenzyme A:cholesterol acyltransferase: Image wherein R is phenyl or 1- or 2-naphthyl which are unsubstituted or may be substituted; R1 is hydrogen or a straight or branched alkyl group having from 1 to 6 carbon atoms; R2 is hydrogen, an aliphatic group, an aromatic group, an aralkyl or diarylalkyl group or R1 and R2 form a carbocyclic group; R3 is hydrogen, an aliphatic group, an aralkyl group wherein the alkyl moiety may contain a carbocyclic entity; R4 is hydrogen, an aliphatic group, SO2R14 , -C(=S)NHR15, -CO2R15, -COR18, or -C(=O)NHR15 wherein R14 is morpholino, phenyl or substituted phenyl; R15 is an alkyl group, phenyl or phenylalkyl wherein the phenyl group may be substituted; and R18 is the same is R15 or is halo-substituted alkyl, 9-fluorenylmethylene or pyrrolidino.

Affiliated with

Also associated with

Rating

Acat inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Acat inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Acat inhibitors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1718967