Acat inhibitors

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C - Chemistry, Metallurgy

07

C

260/263, 260/295

C07C 233/00 (2006.01) C07C 233/06 (2006.01) C07C 233/07 (2006.01) C07C 233/13 (2006.01) C07C 233/18 (2006.01) C07C 233/36 (2006.01) C07C 233/47 (2006.01) C07C 237/04 (2006.01) C07C 237/22 (2006.01) C07C 255/29 (2006.01) C07C 271/22 (2006.01) C07C 275/16 (2006.01) C07C 275/30 (2006.01) C07C 279/30 (2006.01) C07C 317/40 (2006.01) C07C 323/41 (2006.01) C07C 327/42 (2006.01) C07D 207/08 (2006.01) C07D 211/16 (2006.01) C07D 213/40 (2006.01) C07D 213/56 (2006.01) C07D 213/75 (2006.01) C07D 239/42 (2006.01) C07D 2

Patent

CA 2030105

ABSTRACT Novel compounds having acyl-coenzyme A: cholesterol acyltransferase (ACAT) inhibitory activity rendering them useful in controlling blood cholesterol levels of the formula Image wherein Ar is phenyl or 1- or 2-naphthyl, each of which may be substituted or unsubstituted; m and n are zero, one, or two; R3 and R4 are hydrogen or an alkyl group which may be substituted on the terminal carbon with hydroxy or an amine group, or R3 is hydrogen and R4 is the group -NHR10 wherein R10 is hydrogen, -C(=O)-alkyl C1-4, -C(=O)-O-t-C4H9, or -C(=O)OCH2C6H5; and R1 and R2 are hydrogen or an aliphatic, a substituted aliphatic, a substituted alicyclic- aliphatic group, a heteroaliphatic group or NR1R2 taken together forms a monocyclic heterocyclic group.

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