Acat inhibitors and their use in the prevention or treatment...

A - Human Necessities – 61 – K

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A61K 31/357 (2006.01) A61K 45/06 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2669123

The present invention relates to the use of ACAT inhibitors, {e.g. F-1394, Avasimibe (CI-1011), Pactimibe (CS505), Efluimibe (F12511), Eldacimibe, NTE 122, AS-183, KW-3033, E5324, FY087, FCE27677, CI-976, K-604, TEI6522, Octimibate, FR179254, and S 58-035, or mixtures thereof), compositions comprising the same, and methods for preventing or treating fibrosis, for preventing or reducing collagen deposition in a tissue, and in the prevention and reduction of excessive fibrous connective tissue

La présente invention porte sur l'utilisation d'inhibiteurs de ACAT (par exemple, F-1394, Avasimibe (CI-1011), Pactimibe (CS505), Efluimibe (F12511), Eldacimibe, NTE 122, AS-183, KW-3033, E5324, FY087, FCE27677, CI-976, K-604, TEI6522, Octimibate, FR179254 et S 58-035, ou des mélanges de ceux-ci), sur des compositions les contenant et sur des procédés pour la prévention ou le traitement de la fibrose, pour empêcher ou réduire le dépôt de collagène dans un tissu, et dans la prévention et la réduction d'un tissu conjonctif fibreux excessif.

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