C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 1/02 (2006.01)
Patent
CA 2625540
Disclosed herein are accelerants for the formation of oxime-containing compounds from the reaction of a carbonyl-containing compound and a hydroxylamine-containing compound. The oxime-containing compound, the carbonyl- containing compound and the hydroxylamine-containing compound can each be a non-natural amino acid or a non-natural amino acid polypeptide. Also disclosed is the use of such accelerants to form oxime-containing compounds, the resulting oxime-containing compounds, and reaction mixtures containing such accelerants.
La présente invention concerne des accélérateurs destinés à la formation de composés contenant de l~oxime à partir de la réaction d~un composé contenant un groupe carbonyle et d~un composé contenant de l~hydroxylamine. Le composé contenant de l~oxime, le composé contenant un groupe carbonyle et le composé contenant de l~hydroxylamine peuvent être chacun un acide aminé non-naturel ou un polypeptide formé d~acides aminés non-naturels. L~invention concerne également l~utilisation de tels accélérateurs en vue de former des composés contenant de l~oxime, les composés contenant de l~oxime obtenus et des mélanges réactionnels comprenant de tels accélérateurs.
Miao Zhenwei
Tian Feng
Ambrx Inc.
Smart & Biggar
LandOfFree
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