Accelerated progression relapse test

C - Chemistry – Metallurgy – 12 – Q

Patent

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Details

C12Q 1/68 (2006.01) G06F 19/20 (2011.01) C40B 30/04 (2006.01)

Patent

CA 2753971

Disclosed is an accelerated progression relapse test for use in the prognosis of disease states. According to the test disclosed herein, it can be determined whether a patient would benefit from treatment for a disease state or whether the patient's prognosis would not have a high probability of benefit with additional treatment. In particular, the test is useful in determining a patient's prognosis for cancer (breast, colon, lung, etc). For example, the test of the invention can be used to determine the progno-sis for estrogen receptor positive (ER+) breast cancer patients. In the test for ER+ breast cancer patients, four genetic probes are employed that target MK167, CDC6, and SPAG5 gene products. The ER+ breast cancer test stratifies a patient population into two groups, with the low gene expression group identifying a group that is less likely to benefit from additional treatment mea-sures, and a high gene expression group, identifying a group more likely to benefit from additional treatment measures.

La présente invention concerne un test de récidive à progression accélérée destiné au pronostic d'états pathologiques. Le test de l'invention permet de déterminer si le patient pourra tirer profit du traitement de l'état pathologique considéré ou si le pronostic du patient ne montre pas de probabilité élevée de tirer profit d'un supplément de traitement. En particulier, le test permet d'établir un pronostic du patient par rapport au cancer (du sein, du colon, du poumon, etc.). Par exemple, le test de l'invention permet d'établir un pronostic dans le cas de patientes atteintes d'un cancer du sein positif au récepteur de l'strogène (ER+). Dans le test destiné aux patientes à cancer du sein ER+, on emploie quatre sondes génétiques ciblant les produits géniques MK167, CDC6 et SPAG5. Le test pour cancer du sein ER+ répartit une population de patientes en deux groupes, un groupe à basse expression des gènes réunissant des individus moins susceptibles de tirer profit de mesures de traitement complémentaires, et un groupe à haute expression des gènes réunissant des individus plus susceptibles de tirer profit de mesures de traitement complémentaires.

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